https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:35037 Wed 19 Jun 2019 11:33:00 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27369 13), associated with low fibrinogen [median,<0.01g/L;IQR:<0.01-0.9g/L), low factor V levels [median,<5%;IQR:<5-4%], low factor VIII levels [median,40%;IQR:12-79%] and low factor X levels [median,48%; IQR:29-67%]. There were smaller reductions in factors II, IX and VII over time. All factors recovered over 48h post-antivenom. The median INR remained >3 at 6h post-antivenom but had reduced to <2, by 24h. The aPTT had also returned to close to normal (<50sec) at 24h. Factor VII, VIII and IX levels were unusually high pre-antivenom, median peak concentrations of 393%, 307% and 468% respectively. Pre-antivenom venom concentrations and the INR (r=0.20, p=0.02) and aPTT (r=0.19, p=0.03) were correlated (non-parametric Spearman analysis). Conclusions: Russell's viper coagulopathy results in prolonged aPTT, INR, low fibrinogen, factors V, VIII and X which recover over 48h. Severity of clotting abnormalities was associated with venom concentrations.]]> Wed 11 Apr 2018 11:40:46 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:33132 Tue 28 Aug 2018 12:56:55 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41060 Tue 26 Jul 2022 08:15:39 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:27073 4) serum samples were available from 255 Russell's viper (Daboia russelii) envenomed patients. Enzyme-linked immunosorbent assay was used to measure venom, antivenom and venom-antivenom (VAV) complexes. In 79/255 (31%) there was persistent/recurrent venom detected despite antivenom being present. In these post-antivenom samples, VAV was also detected at the same time as venom was detected. Anti-horse (aH) antiserum was bound to UltraLink (UL) resin and added to in vitro venom-antivenom mixtures, and 15 pre- and post-antivenom samples from patients. There was significantly less free venom detected in in vitro venom-antivenom mixtures to which ULaH had been added compared to those without ULaH added. In 9 post-antivenom patient samples the addition of ULaH reduced venom detected by a median of 80% (69%-88%) compared to only 20% in four pre-antivenom samples. This suggests that the detection of persistent/recurrent venom post-antivenom is due to bound and not free venom.]]> Sat 24 Mar 2018 07:25:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50633 Mon 31 Jul 2023 15:59:57 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:22947 Fri 13 Jul 2018 15:45:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15310 Fri 09 Sep 2016 16:08:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45713 Fri 04 Nov 2022 10:27:59 AEDT ]]>